Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Lucknow, India.
Contraception. 2010 Apr;81(4):275-80. doi: 10.1016/j.contraception.2009.11.007. Epub 2010 Jan 4.
This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed.
这篇文章简要回顾了已发表的关于非甾体、每周口服一次的避孕药中顺式美仑孕酮(INN:奥孕美仑)药代动力学数据的信息。该药物是一种独特的以需求为导向的避孕药物,已被纳入印度国家家庭福利计划。自 1991 年以来,顺式美仑孕酮一直被用作以需求为导向的避孕药,并被用于治疗子宫功能失调性出血。本文讨论了其吸收、组织分布、消除和动力学相互作用的信息。