多取代手性色满的不对称合成——有机催化的氧杂-迈克尔-硝基-迈克尔串联反应

Asymmetric synthesis of polysubstituted chiral chromans an organocatalytic oxa-Michael-nitro-Michael domino reaction.

作者信息

Tang Cheng-Ke, Feng Kai-Xiang, Xia Ai-Bao, Li Chen, Zheng Ya-Yun, Xu Zhen-Yuan, Xu Dan-Qian

机构信息

Catalytic Hydrogenation Research Centre, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology Hangzhou 310014 China

出版信息

RSC Adv. 2018 Jan 17;8(6):3095-3098. doi: 10.1039/c7ra13525d. eCollection 2018 Jan 12.

A catalytic asymmetric method for the synthesis of polysubstituted chromans an oxa-Michael-nitro-Michael reaction has been developed. The squaramide-catalyzed domino reaction of 2-hydroxynitrostyrenes with -β-nitroolefins produced chiral chromans with excellent enantioselectivities (up to 99% ee), diastereoselectivities (up to >20 : 1 dr), and moderate to good yields (up to 82%).