Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Cell Host Microbe. 2010 Mar 18;7(3):179-81. doi: 10.1016/j.chom.2010.03.001.
Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.
HIV-1 基因组的有效转录涉及 RNA 聚合酶 II 与病毒蛋白 Tat 及其辅助因子协同作用，在一个高度协调的过程中进行。现在，Pagans 及其同事报告称，赖氨酸甲基转移酶 Set7/9-KMT7 与 Tat 结合，以刺激整合的前病毒中 RNA 聚合酶 II 的延伸。Set7/9-KMT7 还甲基化 Tat，从而增强 Tat 的功能。
