Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
J Neuroimmunol. 2010 Apr 15;221(1-2):68-72. doi: 10.1016/j.jneuroim.2010.02.007. Epub 2010 Mar 15.
Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG biomarker. AQP4 is expressed as two isoforms: M1 and M23, which have different functions in the central nervous system (CNS). We characterized the expression pattern of these AQP4 isoform mRNAs in humans and found a pattern of AQP4 expression that correlates with NMO disease localization. The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices.
视神经脊髓炎（NMO）是一种破坏性的神经炎症性疾病，专门针对脊髓和视神经。水通道蛋白 4（AQP4）是 NMO-IgG 生物标志物的靶标。AQP4 表达为两种异构体：M1 和 M23，它们在中枢神经系统（CNS）中具有不同的功能。我们对这些 AQP4 异构体 mRNA 在人类中的表达模式进行了特征描述，并发现了与 NMO 疾病定位相关的 AQP4 表达模式。M1:M23 mRNA 的比例在视神经和脊髓中最高，其次是脑干，然后是大脑和小脑皮质。
