López María de Los Angeles, Bojanich María V, Jacobacci Juan M, Sercic Clara, Michelini Alicia, Alonso José M
Area de Inmunología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Resistencia, Chaco.
Medicina (B Aires). 2010;70(1):75-8.
In order to evaluate the association between the infection by Toxocara canis and the symptoms of asthma in children from a subtropical region with high prevalence of toxocariasis, 47 asthmatic children and 53 non-asthmatics as a control group were studied. A complete physical examination was performed and clinical and epidemiological data were registered. In asthmatic children the frequency and severity of symptoms were classified in grades I to IV. The presence of anti-Toxocara canis antibodies in both groups was evaluated employing a solid phase ELISA method with excretion/secretion antigens, and total Ig E was also measured. Results showed a total seropositivity of 55%, 57.4% in children with asthma and 52.8% in the control group. Among asthmatics with severe symptoms (grade II, III and IV), there was a 67.7% of seropositivity while in children with symptoms of grade I there was a 37.5% (p = 0.0470). The infection with T. canis could act as a co-factor increasing the severity of the symptoms of bronchial asthma.
为了评估在蛔虫病高发的亚热带地区，犬弓首蛔虫感染与儿童哮喘症状之间的关联，对47名哮喘儿童和53名非哮喘儿童作为对照组进行了研究。进行了全面的体格检查并记录了临床和流行病学数据。在哮喘儿童中，症状的频率和严重程度分为I至IV级。采用含排泄/分泌抗原的固相ELISA方法评估两组中犬弓首蛔虫抗体的存在情况，并测定总IgE。结果显示总血清阳性率为55%，哮喘儿童为57.4%，对照组为52.8%。在有严重症状（II、III和IV级）的哮喘患者中，血清阳性率为67.7%，而在有I级症状的儿童中为37.5%（p = 0.0470）。犬弓首蛔虫感染可能作为一个辅助因素增加支气管哮喘症状的严重程度。
