Bazargan Nasrin, Lari Azadeh Nasri, Borhani Mehdi, Fasihi Harandi Majid
Department of Pediatrics, Afzalipour Medical Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Front Med (Lausanne). 2022 Sep 29;9:920182. doi: 10.3389/fmed.2022.920182. eCollection 2022.
Asthma is a common respiratory disease affecting humans. Helminth parasites, including species, have been implicated as predisposing factors of asthma. However, various studies present different findings on asthma- association. Herein, we investigated the association of asthma manifestations with seropositivity in a case-control setting on 248 participants (147 women and 101 men), with 124 healthy individuals as the control group and 124 patients known to have asthma based on the medical records of asthma clinics of Kerman University of Medical Sciences. Consequently, we presented a scoping review of all previous studies carried out on this topic, summarizing current findings and existing knowledge on this issue. Of 248 participants, 31 (12.5%) were -seropositive, of which 19 (15.3%) were in the patient group and 12 (9.7%) in the control group. A significant relationship was found between asthma severity and age in -seropositive individuals ( < 0.04). We found no significant relationship between asthma and seropositivity. We identified 7,724 related records in three major scientific databases, NCBI PubMed, Scopus, and Google Scholar. The review of the literature showed that there are 80 published articles on asthma- relationship with contradictory findings. More than half of the studies were performed in only four countries, namely, Brazil, the Netherlands, the United States, and Iran. The study population in 70% of the studies were children, and few studies investigated asthma- association in adults. The most common study designs for investigating the association of asthma and seropositivity were cross-sectional (35.0%), case-control (27.5%), and animal experimental (12.5%) studies. This study found no significant relationship between asthma manifestations and toxocariasis in a case-control setting. However, a scoping review of the current literature suggests that further experimental and field longitudinal cohort studies are required to elucidate the nature of asthma- interaction in humans.
哮喘是一种影响人类的常见呼吸道疾病。包括某些种类在内的蠕虫寄生虫被认为是哮喘的诱发因素。然而，各种研究在哮喘关联性方面呈现出不同的结果。在此，我们在一项病例对照研究中，对248名参与者（147名女性和101名男性）进行了哮喘表现与[某种寄生虫]血清阳性之间关联性的调查，以124名健康个体作为对照组，根据克尔曼医科大学哮喘诊所的病历，选取124名已知患有哮喘的患者作为病例组。因此，我们对以前关于该主题的所有研究进行了范围综述，总结了当前关于此问题的研究结果和现有知识。在248名参与者中，31名（12.5%）为[某种寄生虫]血清阳性，其中19名（15.3%）在病例组，12名（9.7%）在对照组。在[某种寄生虫]血清阳性个体中，发现哮喘严重程度与年龄之间存在显著关系（P<0.04）。我们发现哮喘与[某种寄生虫]血清阳性之间没有显著关系。我们在三个主要科学数据库，即美国国立医学图书馆生物医学文献数据库（NCBI PubMed）、Scopus和谷歌学术中识别出7724条相关记录。文献综述表明，有80篇关于哮喘与[某种寄生虫]关系的已发表文章，结果相互矛盾。超过一半的研究仅在四个国家进行，即巴西、荷兰、美国和伊朗。70%的研究人群为儿童，很少有研究调查成年人中哮喘与[某种寄生虫]的关联性。调查哮喘与[某种寄生虫]血清阳性之间关联性最常见的研究设计是横断面研究（35.0%）、病例对照研究（27.5%）和动物实验研究（12.5%）。本研究在病例对照研究中未发现哮喘表现与弓蛔虫病之间存在显著关系。然而，当前文献的范围综述表明，需要进一步开展实验性和现场纵向队列研究，以阐明人类中哮喘与[某种寄生虫]相互作用的本质。
