Rojas Juan Ignacio, González Sergio J, Patrucco Liliana, Cristiano Edgardo
Sección de Neuroinmunología y Enfermedades Desmielinizantes, Servicio de Neurología, Hospital Italiano de Buenos Aires.
Medicina (B Aires). 2010;70(1):79-86.
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans.
多发性硬化症（MS）是一种中枢神经系统（CNS）的自身免疫性炎性脱髓鞘疾病。大多数自身免疫性疾病是由于外周耐受功能障碍，导致针对自身抗原（其中大多数至今仍不明）的炎症反应异常激活所致。调节性T细胞对于维持外周耐受、预防自身免疫性疾病和限制慢性炎症状态至关重要。基于这一认识，调节性T细胞已成为包括MS在内的自身免疫性疾病病理生理学的关键组成部分。本综述汇集了关于调节性T细胞在MS（人类中最常见的中枢神经系统自身免疫性疾病）中的作用和功能的现有知识。
