Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Endocr Relat Cancer. 2010 Mar 8;17(2):329-34. doi: 10.1677/ERC-09-0284. Print 2010 Jun.
The changes of cancer incidence upon immigration have been used as an estimator of environmental influence on cancer risk. The previous immigrant studies have indicated that the origins of testicular cancer are at an early age in life, probably in the intrauterine period. We wanted to reexamine the critical periods on histology-specific testicular cancer in sons of immigrants to Sweden. We used the nationwide Swedish Family-Cancer Database to calculate standardized incidence ratios (SIRs) for testicular cancer in sons of parents immigrating to Sweden from low- and high-risk countries compared with the native Swedes. Among the large immigrant groups, the SIRs for sons of two Finnish and Asian parents were decreased if the sons were born outside Sweden. The sons of a Danish immigrant couple showed an increased risk of testicular cancer. The changes in SIR were most systematic for seminoma. The present patterns of testicular cancer risk among sons of immigrants point to the early environmental risk factors, which influence the risk probably after the intrauterine period. These factors appear to influence seminoma risk in a more enduring way than they influence non-seminoma.
移民后癌症发病率的变化可用作评估环境对癌症风险影响的指标。之前的移民研究表明，睾丸癌的起源是在生命早期，可能在子宫内。我们想重新检查移民到瑞典的儿子的组织学特异性睾丸癌的关键时期。我们使用全国性的瑞典家庭癌症数据库，计算了来自低风险和高风险国家的移民父母的儿子与瑞典本地人相比的睾丸癌标准化发病比 (SIR)。在较大的移民群体中，如果儿子出生在瑞典以外，来自两个芬兰和亚洲父母的儿子的 SIR 降低。丹麦移民夫妇的儿子患睾丸癌的风险增加。SIR 的变化在精原细胞瘤中最为系统。移民儿子的睾丸癌风险模式表明，早期环境风险因素可能在子宫内之后就会影响风险。这些因素似乎比非精原细胞瘤更持久地影响精原细胞瘤的风险。
