Clinique Equine de Livet, Cour Samson, 14140 Saint Michel de Livet, France.
Vet Rec. 2010 Mar 13;166(11):324-8. doi: 10.1136/vr.b4799.
Three groups of horses scheduled for arthroscopic surgery were premedicated with 0.025 mg/kg acepromazine, 88 microg/kg romifidine and 25 mg/kg guaifenesin, and anaesthesia was induced with 2.2 mg/kg ketamine. In group 1 (14 horses), anaesthesia was maintained by halothane vaporised in oxygen, with supplementary doses of 20 microg/kg romifidine and 0.5 mg/kg ketamine every 20 minutes. The 17 horses in group 2 were maintained as for group 1; however, an additional dose of 0.05 mg/kg butorphanol was administered before the first incision. The 14 horses in group 3 were maintained as for group 2, except that the dose of romifidine was halved to 10 microg/kg. The mean (sd) dose of vaporised halothane (6.5 [1.1], 4.8 [1.3] and 4.8 [1.3] microl/kg/minute, for groups 1, 2 and 3, respectively), vaporiser dial setting (2.3 [0.2],1.6 [0.4] and 1.3 [0.1] per cent) and dose of dobutamine administered to correct episodes of hypotension (0.16 [0.08], 0.07 [0.09] and 0.0 [0.0] microg/kg/minute) were all significantly lower in groups 2 and 3 than in group 1. Mean arterial blood pressure was significantly higher in groups 2 and 3 than in group 1 (71 [3], 74 [5] and 80 [5] mmHg, for groups 1, 2 and 3, respectively).
三组马接受关节镜手术,术前分别用 0.025mg/kg 乙酰丙嗪、88μg/kg 罗米非定和 25mg/kg 愈创甘油醚预处理,然后用 2.2mg/kg 氯胺酮诱导麻醉。第 1 组(14 匹马)用氧化亚氮中的氟烷维持麻醉,每 20 分钟给予 20μg/kg 罗米非定和 0.5mg/kg 氯胺酮的补充剂量。第 2 组(17 匹马)与第 1 组相同;然而,在第一次切口前给予 0.05mg/kg 布托啡诺。第 3 组(14 匹马)与第 2 组相同,只是罗米非定的剂量减半至 10μg/kg。第 1、2 和 3 组的氟烷蒸发剂量(6.5[1.1]、4.8[1.3]和 4.8[1.3]µl/kg/min)、蒸发器刻度设置(2.3[0.2]、1.6[0.4]和 1.3[0.1]%)和用于纠正低血压发作的多巴酚丁胺剂量(0.16[0.08]、0.07[0.09]和 0.0[0.0]µg/kg/min)均明显低于第 1 组。第 2 组和第 3 组的平均动脉血压明显高于第 1 组(分别为 71[3]、74[5]和 80[5]mmHg)。