Department of Microbiology and Immunology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, USA.
Cell Mol Immunol. 2010 Sep;7(5):334-40. doi: 10.1038/cmi.2010.8. Epub 2010 Mar 15.
The complement system, a key component of innate immunity, is a first-line defender against foreign pathogens such as HIV-1. The role of the complement system in HIV-1 pathogenesis appears to be multifaceted. Although the complement system plays critical roles in clearing and neutralizing HIV-1 virions, it also represents a critical factor for the spread and maintenance of the virus in the infected host. In addition, complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of HIV-1. Some novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against HIV-1. In this paper, we will review these diverse roles of complement in HIV-1 infection.
补体系统是先天免疫系统的关键组成部分,是抵御 HIV-1 等外来病原体的第一道防线。补体系统在 HIV-1 发病机制中的作用似乎是多方面的。尽管补体系统在清除和中和 HIV-1 病毒颗粒方面发挥着关键作用,但它也是病毒在感染宿主中传播和维持的关键因素。此外,HIV-1 包膜中存在的补体调节因子,如人 CD59,可防止补体介导的 HIV-1 裂解。目前提出了一些新的方法,通过增强抗体依赖性补体对 HIV-1 的活性来对抗 HIV-1 感染。本文将综述补体在 HIV-1 感染中的这些不同作用。