Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Immune Netw. 2010 Feb;10(1):26-34. doi: 10.4110/in.2010.10.1.26. Epub 2010 Feb 28.
Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled particulate antigens. The family of Fcgamma receptors (FcgammaRs) has emerged as central regulators for modulating both pro-and anti-inflammatory responses. However, the role of FcgammaRs in the development of HP has not been investigated yet.
To explore the functional roles of FcgammaRs in HP, FcgammaR(-/-) and B6 mice were challenged with Saccharopolyspora rectivirgula (SR) antigen intranasally, and compared these mice in terms of the histological change, infiltrated immune cells in BALF and in vitro immune responses.
FcgammaR(-/-) mice exhibited attenuation of HP in terms of histological alterations, and reduced numbers of neutrophils and macrophages in and the increased CD4:CD8 ratio of bronchoalveolar lavage fluid. The lungs of FcgammaR(-/-) mice showed high production of Th2 cytokine such as IL-4 and slightly low production of Th1 cytokine, INF-gamma compared to those of B6 mice. However, SR-specific adaptive immune responses of FcgammaR(-/-) mice were similar to those of B6 mice.
These results demonstrate that activating Fcgamma receptors play an important role in activating neutrophils and macrophages in pulmonary inflammation and inducing Th1 differentiation by regulating cytokine expression in SR-induced HP.
过敏性肺炎（HP）是一种间质性肺疾病，是由吸入的颗粒性抗原反复暴露引起的。Fcγ 受体（FcγRs）家族已成为调节促炎和抗炎反应的核心调节剂。然而，FcγRs 在 HP 发展中的作用尚未得到研究。
为了探讨 FcγRs 在 HP 中的功能作用，用 Saccharopolyspora rectivirgula（SR）抗原经鼻腔挑战 FcγR（-/-）和 B6 小鼠，并比较这些小鼠的组织学变化、BALF 中浸润的免疫细胞和体外免疫反应。
FcγR（-/-）小鼠在组织学改变方面表现出 HP 减弱，并且在和支气管肺泡灌洗液中的中性粒细胞和巨噬细胞数量减少，CD4：CD8 比值增加。与 B6 小鼠相比，FcγR（-/-）小鼠的肺部产生了高浓度的 Th2 细胞因子，如 IL-4，而 Th1 细胞因子，IFN-γ 的产量略低。然而，FcγR（-/-）小鼠对 SR 的适应性免疫反应与 B6 小鼠相似。
这些结果表明，激活 Fcγ 受体通过调节 SR 诱导的 HP 中的细胞因子表达，在肺部炎症中激活中性粒细胞和巨噬细胞，并诱导 Th1 分化中发挥重要作用。
