Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Cancer Causes Control. 2010 Jul;21(7):1025-32. doi: 10.1007/s10552-010-9530-9. Epub 2010 Mar 13.
The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners.
The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02-3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years.
This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.
糖尿病与前列腺癌风险之间的关联已在西方人群的先前前瞻性队列研究中进行了检验。然而，亚洲人群的队列研究尚无证据，因为他们的生活方式与西方人有很大的不同。
作者在 1995 年至 2003 年随访的大崎队列中检查了糖尿病与前列腺癌风险之间的关系，在 22458 名日本男性中发现了 230 例新的前列腺癌病例。使用自我管理问卷收集了包括糖尿病状态在内的基线信息。使用 Cox 比例风险回归模型估计了危险比（HR）和 95％置信区间（CI）。
尽管在该人群中，糖尿病史与总前列腺癌的风险无关，但根据前列腺癌的临床分期进行分层后，患有糖尿病的患者患有晚期前列腺癌的风险更高，经多变量调整后的 HR=1.89（95％CI：1.02-3.50）。当我们将前 2 年内发生的病例排除在分析之外时，这种关系仍然很牢固。
这项基于人群的前瞻性队列研究表明，糖尿病史与晚期前列腺癌的发生率增加有关。
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