糖尿病与癌症：代谢关联、治疗挑战及天然产物的作用
Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products.
作者信息
Talib Wamidh H, Mahmod Asma Ismail, Abuarab Sara Feras, Hasen Eliza, Munaim Amer A, Haif Shatha Khaled, Ayyash Amani Marwan, Khater Samar, Al-Yasari Intisar Hadi, Kury Lina T Al
机构信息
Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931-166, Jordan.
Department of Genetic Engineering, College of Biotechnology, Al-Qasim Green University, Babylon 00964, Iraq.
出版信息
Molecules. 2021 Apr 10;26(8):2179. doi: 10.3390/molecules26082179.
Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.
癌症被认为是全球第二大致死原因，2018年约有960万人死于癌症。在全球范围内，约六分之一的死亡是由癌症引起的。人们发现糖尿病与癌症发生之间存在很强的相关性，其中与2型糖尿病（T2DM）的相关性最为明显。研究证明，血糖水平升高参与细胞增殖和癌细胞进展。然而，评估传统疗法对糖尿病癌症患者疗效的研究有限。在这篇综述中，将讨论癌症与糖尿病之间的相关性、两种疾病相互作用的机制，以及治疗糖尿病和癌症患者时面临的治疗挑战及克服这些挑战的可能解决方案。还讨论了针对这两种疾病的天然产物及其详细作用机制。这篇综述将为研究人员和医生提供坚实的基础，以便测试天然产物作为辅助替代疗法来治疗糖尿病患者的癌症。
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