终止组蛋白合成以维持着丝粒完整性。
Terminating histone synthesis to preserve centromere integrity.
机构信息
The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.
出版信息
Dev Cell. 2010 Mar 16;18(3):335-6. doi: 10.1016/j.devcel.2010.03.004.
PMID:20230740
Abstract
Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disrupts centromeric chromatin structure.
摘要
当细胞进入 S 期时，组蛋白蛋白合成被激活，以便将新复制的 DNA 包装成染色质。在本期《发育细胞》中，Takayama 及其同事阐明了在 S. pombe 中 S 期结束时沉默组蛋白表达的机制。未能关闭组蛋白的表达会破坏着丝粒染色质结构。
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