Decker C F, Parenti D M
Department of Medicine, George Washington University Medical Center, Washington, D.C. 20037.
J Acquir Immune Defic Syndr (1988). 1991;4(6):603-6.
Two cases of invasive aspergillosis in AIDS patients are reported and previously reported AIDS-related cases are reviewed. Only one-half of all cases were diagnosed antemortem. Outcome is poor despite antifungal and surgical therapy. Normal phagocytic function is important in host defense against Aspergillus species. HIV-infected patients may have impaired phagocytic function as a result of antiretroviral therapy or treatment of opportunistic infection, or due to HIV infection itself. As the lifespans of HIV-infected patients are extended by antiretroviral therapy, an increasing awareness of Aspergillus infection as an opportunistic pathogen will be necessary.
报告了两例艾滋病患者的侵袭性曲霉病病例，并对先前报告的艾滋病相关病例进行了回顾。所有病例中只有一半在生前得到诊断。尽管进行了抗真菌和手术治疗，但预后很差。正常的吞噬功能在宿主抵御曲霉菌种方面很重要。感染艾滋病毒的患者可能由于抗逆转录病毒疗法、机会性感染的治疗或艾滋病毒感染本身而导致吞噬功能受损。随着抗逆转录病毒疗法延长了感染艾滋病毒患者的寿命，有必要提高对曲霉感染作为一种机会性病原体的认识。
