Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109-2200, USA.
J Biol Chem. 2010 May 7;285(19):14071-7. doi: 10.1074/jbc.R109.094003. Epub 2010 Mar 15.
The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR signaling networks in cellular physiology.
哺乳动物雷帕霉素靶蛋白(mTOR)激酶对多种环境信号做出响应,从而控制着众多细胞过程。mTOR 形成了至少两种不同信号复合物的催化核心,这两种复合物被称为 mTOR 复合物 1 和 2。复合物对 mTOR 抑制剂雷帕霉素的敏感性不同、具有独特的结合蛋白、不同的底物以及独特的细胞功能,区分了这两种复合物。在这里,我们综述了近年来人们对细胞生理学中 mTOR 信号网络的调控和功能的理解进展。