Zhou Hongyu, Huang Shile
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA.
Crit Rev Eukaryot Gene Expr. 2010;20(1):1-16. doi: 10.1615/critreveukargeneexpr.v20.i1.10.
Tumor cell migration is a key step in the formation of cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serinethreonine kinase, has been intensely studied for over a decade as a central regulator of cell growth, proliferation, differentiation, and survival. Recent data have shown that mTOR also plays a critical role in the regulation of tumor cell motility and cancer metastasis. Here, we briefly review recent advances regarding mTOR signaling in tumor cell motility. We also discuss recent findings about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell motility in vitro and metastasis in vivo.
肿瘤细胞迁移是癌症转移形成过程中的关键步骤。雷帕霉素的哺乳动物靶点（mTOR）是一种高度保守且广泛表达的丝氨酸 - 苏氨酸激酶，作为细胞生长、增殖、分化和存活的核心调节因子，十多年来一直受到深入研究。最近的数据表明，mTOR在肿瘤细胞运动性和癌症转移的调节中也起着关键作用。在此，我们简要回顾一下关于mTOR信号传导在肿瘤细胞运动性方面的最新进展。我们还将讨论雷帕霉素（一种mTOR的特异性抑制剂）在体外抑制细胞运动性和体内抑制转移的机制的最新研究发现。
