Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille Cedex 9, France.
Immunol Cell Biol. 2010 May-Jun;88(4):366-75. doi: 10.1038/icb.2010.34. Epub 2010 Mar 16.
Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and the function of these five DC subsets before and after their migration to cutaneous draining lymph nodes. Moreover, it integrates this information into a unifying model that emphasizes the similarities that exist among the mouse DC subsets that are found in both lymphoid and nonlymphoid tissues.
利用“敲除”小鼠来追踪和清除明显表达朗格汉斯细胞（CD207）基因的树突状细胞（DC），已经有可能在皮肤中鉴定出五个 DC 亚群，并评估它们之间是否存在功能特化。本综述总结了最近关于这些 DC 亚群在迁移到皮肤引流淋巴结前后的表型和功能的信息。此外，它将这些信息整合到一个统一的模型中，强调了在淋巴组织和非淋巴组织中发现的小鼠 DC 亚群之间存在的相似性。
