Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA.
Laryngoscope. 2010 Apr;120(4):832-7. doi: 10.1002/lary.20812.
OBJECTIVES/HYPOTHESIS: To evaluate differences in endoscopy exam, olfactory function, and quality-of-life (QOL) status after endoscopic sinus surgery (ESS) for patients with and without bilateral middle turbinate (BMT) resection.
Open, prospective, multi-institutional cohort.
Subjects completing enrollment interviews, computed tomography (CT), and endoscopy exam were asked to provide pre- and postoperative responses to the Smell Identification Test (SIT), Rhinosinusitis Disability Index (RSDI), Chronic Sinusitis Survey (CSS), and the Medical Outcomes Study Short Form-36 Health Survey (SF-36). Bivariate and multivariate analyses were performed at the .05 alpha level.
Forty-seven subjects with BMT resection were compared to 195 subjects without BMT resection with a mean follow-up of 17.4 months postoperatively. Patients with BMT resection were more likely to have asthma (P = .001), aspirin intolerance (P = .022), nasal polyposis (P = .025), and prior sinus surgery (P = .002). Patients with BMT resection had significantly higher baseline disease burden measured by endoscopy, CT, and SIT scores (P < .001). No significant differences in improvement were found in RSDI, CSS, or SF-36 scores between patients with BMT resection and those with BMT preservation (P > .05). Patients undergoing BMT resection were more likely to show improvements in mean endoscopy (-4.5 +/- 5.2 vs. -1.9 +/- 4.3; P = .005) and olfaction (5.3 +/- 10.8 vs. 1.3 +/- 7.6, P = .045) compared to those with BMT preservation.
This investigation found no difference in QOL outcomes in patients with BMT preservation vs. resection. Patients undergoing BMT resection did, however, show greater improvements in endoscopy and SIT scores, which persisted after controlling for confounding factors.
目的/假设:评估伴有和不伴有双侧中鼻甲(BMT)切除的内镜鼻窦手术(ESS)后内镜检查、嗅觉功能和生活质量(QOL)状况的差异。
开放、前瞻性、多机构队列。
完成入组访谈、计算机断层扫描(CT)和内镜检查的受试者被要求在术前和术后提供 Smell Identification Test(SIT)、Rhinosinustis Disability Index(RSDI)、Chronic Sinusitis Survey(CSS)和 Medical Outcomes Study Short Form-36 Health Survey(SF-36)的反应。在.05 alpha 水平进行了双变量和多变量分析。
将 47 例 BMT 切除患者与 195 例无 BMT 切除患者进行了比较,术后平均随访 17.4 个月。BMT 切除患者更有可能患有哮喘(P =.001)、阿司匹林不耐受(P =.022)、鼻息肉(P =.025)和既往鼻窦手术(P =.002)。BMT 切除患者的基线疾病负担在内镜、CT 和 SIT 评分方面显著更高(P <.001)。在 RSDI、CSS 或 SF-36 评分方面,BMT 切除患者与 BMT 保留患者之间没有发现显著的改善差异(P >.05)。与 BMT 保留患者相比,BMT 切除患者的内镜检查(-4.5 +/- 5.2 与-1.9 +/- 4.3;P =.005)和嗅觉(5.3 +/- 10.8 与 1.3 +/- 7.6,P =.045)的平均改善更显著。
本研究发现 BMT 保留与切除患者的 QOL 结局无差异。然而,接受 BMT 切除的患者在控制混杂因素后,内镜检查和 SIT 评分的改善更为显著。