APP 加工酶及产物概述。
An overview of APP processing enzymes and products.
机构信息
Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Neuromolecular Med. 2010 Mar;12(1):1-12. doi: 10.1007/s12017-009-8104-z.
The generation of amyloid beta-peptide (A beta) by enzymatic cleavages of the beta-amyloid precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While the basic process of beta- and gamma-secretase-mediated generation of A beta is text book knowledge, new aspects of A beta and other cleavage products have emerged in recent years. Also our understanding of the enzymes involved in APP proteolysis has increased dramatically. All of these discoveries contribute to a more complete understanding of APP processing and the physiologic and pathologic roles of its secreted and intracellular protein products. Understanding APP processing is important for any therapeutic strategy aimed at reducing A beta levels in AD. In this review, we provide a concise description of the current state of understanding the enzymes involved in APP processing, the cleavage products generated by different processing patterns, and the potential functions of those cleavage products.
淀粉样β肽（Aβ）的产生是由β淀粉样前体蛋白（APP）的酶切裂解引起的，这一直是阿尔茨海默病（AD）研究的中心。虽然β-和γ-分泌酶介导的 Aβ产生的基本过程是教科书中的知识，但近年来出现了 Aβ和其他裂解产物的新方面。此外，我们对参与 APP 蛋白水解的酶的理解也有了显著提高。所有这些发现都有助于更全面地了解 APP 的加工以及其分泌和细胞内蛋白产物的生理和病理作用。了解 APP 的加工对于任何旨在降低 AD 中 Aβ水平的治疗策略都很重要。在这篇综述中，我们简要描述了目前对参与 APP 加工的酶、不同加工模式产生的裂解产物以及这些裂解产物的潜在功能的理解。
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