异生物质和疾病状态对肝脏 ABCC 转运体的调节。
Regulation of hepatic ABCC transporters by xenobiotics and in disease states.
机构信息
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, 06269, USA.
出版信息
Drug Metab Rev. 2010 Aug;42(3):482-538. doi: 10.3109/03602531003654915.
The subfamily of ABCC transporters consists of 13 members in mammals, including the multidrug resistance-associated proteins (MRPs), sulfonylurea receptors (SURs), and the cystic fibrosis transmembrane conductance regulator (CFTR). These proteins play roles in chemical detoxification, disposition, and normal cell physiology. ABCC transporters are expressed differentially in the liver and are regulated at the transcription and translation level. Their expression and function are also controlled by post-translational modification and membrane-trafficking events. These processes are tightly regulated. Information about alterations in the expression of hepatobiliary ABCC transporters could provide important insights into the pathogenesis of diseases and disposition of xenobiotics. In this review, we describe the regulation of hepatic ABCC transporters in humans and rodents by a variety of xenobiotics, under disease states and in genetically modified animal models deficient in transcription factors, transporters, and cell-signaling molecules.
ABCC 转运子亚家族包括哺乳动物中的 13 个成员，包括多药耐药相关蛋白 (MRP)、磺酰脲受体 (SUR) 和囊性纤维化跨膜电导调节因子 (CFTR)。这些蛋白在化学解毒、处置和正常细胞生理学中发挥作用。ABCC 转运子在肝脏中表达不同，并在转录和翻译水平受到调节。它们的表达和功能也受到翻译后修饰和膜运输事件的控制。这些过程受到严格调控。关于肝胆 ABCC 转运子表达改变的信息可以为疾病的发病机制和外源性物质的处置提供重要的见解。在这篇综述中，我们描述了各种外源性物质、疾病状态以及缺乏转录因子、转运子和细胞信号分子的基因修饰动物模型对人类和啮齿动物肝脏 ABCC 转运子的调节。
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