Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China.
J Sex Med. 2011 Dec;8(12):3345-53. doi: 10.1111/j.1743-6109.2010.01740.x. Epub 2010 Mar 8.
Antipsychotic drug-induced sexual dysfunction is a common and problematic side effect, which may diminish quality of life and lead to treatment noncompliance. Up to date, there is still a scarcity of basic research regarding the chronic effects of most antipsychotic agents on sexual behavior.
The present study investigated the effect of a range of doses of three antipsychotic drugs (haloperidol, risperidone, and quetiapine) on male rat sexual competence following chronic administration.
Twelve groups of Sprague-Dawley rats (n = 7 each) received by gavage haloperidol (0.25, 0.5, or 1 mg/kg), risperidone (0.125, 0.25, or 0.5 mg/kg), quetiapine (10, 20, and 40 mg/kg) or vehicle (distilled water) in the corresponding control groups, respectively, once daily for 21 days. Sexual function was evaluated by the copulatory behavior test 10 hours after the last dose.
The male rat behavioral parameters of copulatory test.
Sexual function was widely and significantly suppressed by high dose haloperidol (1 mg/kg) after 21 days administration compared with the control group, which included both frequency and latency of intromission and ejaculation. Only ejaculation latency was significantly impaired after administration with 0.5 mg/kg haloperidol. Compared with the control group, high dose risperidone (0.5 mg/kg) significantly decreased the frequency of mounting. There were no significant changes in sexual behavior with the lower doses of either haloperidol or risperidone. Sexual behavior was not influenced by any dose of quetiapine.
Haloperidol and risperidone, but not quetiapine, could impair sexual competence in a dose-related manner in male rats.
抗精神病药物引起的性功能障碍是一种常见且棘手的副作用，它可能会降低生活质量并导致治疗不依从。迄今为止，关于大多数抗精神病药物对性行为的慢性影响，基础研究仍然很少。
本研究旨在探讨三种抗精神病药物（氟哌啶醇、利培酮和喹硫平）在慢性给药后对雄性大鼠性能力的影响。
12 组 Sprague-Dawley 大鼠（每组 7 只）分别灌胃氟哌啶醇（0.25、0.5 或 1mg/kg）、利培酮（0.125、0.25 或 0.5mg/kg）、喹硫平（10、20 和 40mg/kg）或相应的对照组（蒸馏水），每天 1 次，连续 21 天。末次给药后 10 小时通过交配行为试验评估性功能。
雄性大鼠交配试验行为参数。
与对照组相比，21 天高剂量氟哌啶醇（1mg/kg）给药后，性功能广泛且显著受到抑制，包括插入和射精的频率和潜伏期。仅给予 0.5mg/kg 氟哌啶醇后，射精潜伏期显著受损。与对照组相比，高剂量利培酮（0.5mg/kg）显著降低了交配频率。氟哌啶醇或利培酮的低剂量对性行为没有显著变化。喹硫平的任何剂量均不影响性行为。
氟哌啶醇和利培酮，而不是喹硫平，可在雄性大鼠中以剂量相关的方式损害性能力。
