原核生物泛素样蛋白为分枝杆菌蛋白酶体底物提供双部分降解基序。
Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates.
机构信息
New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236, New York, NY 10016, USA.
出版信息
J Bacteriol. 2010 Jun;192(11):2933-5. doi: 10.1128/JB.01639-09. Epub 2010 Mar 16.
Abstract
Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation.
摘要
原核泛素样蛋白（Pup）是一种翻译后修饰蛋白，可将蛋白质靶向到分枝杆菌蛋白酶体进行降解。我们发现 Pup 无规则的氨基末端对于降解是必需的，而螺旋状的羧基末端则介导其与蛋白质的结合。因此，Pup 具有与泛素化酶相互作用或启动蛋白酶体降解的不同区域。
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