利用 H2O2 和 P2O5 的水溶液将缺电子的苯并[b]噻吩容易地氧化为相应的砜。
Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.
机构信息
Cancer Research UK Protein-Protein Interactions Drug Discovery Research Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.
出版信息
Chem Commun (Camb). 2010 Apr 7;46(13):2289-91. doi: 10.1039/b924333j. Epub 2010 Jan 25.
DOI:10.1039/b924333j
PMID:20234935
Abstract
A facile oxidation for the clean conversion of benzo[b]thiophenes to their corresponding sulfones is described employing an aqueous solution of H(2)O(2) and P(2)O(5); the solution can be prepared and stored on a multi-gram scale with a shelf-life of up to two weeks.
摘要
一种简便的氧化方法，可利用 H(2)O(2)和 P(2)O(5)的水溶液将苯并[b]噻吩干净地转化为相应的砜；该溶液可在多克规模下制备和储存，保质期长达两周。
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