一名急性淋巴细胞白血病患儿鞘内联合化疗后发生急性致命性脊髓脑病。
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia.
作者信息
von der Weid N X, de Crousaz H, Beck D, Deonna T, Miklossy J, Janzer R C
机构信息
Pediatric Department, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
出版信息
Med Pediatr Oncol. 1991;19(3):192-8. doi: 10.1002/mpo.2950190309.
We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.
我们报告了一例12岁女孩因鞘内预防性注射甲氨蝶呤和阿糖胞苷导致致命性中毒性脑脊髓病的病例，其具有特征性的进行性症状，28天后死亡。神经病理学改变的部位和类型支持甲氨蝶呤和/或阿糖胞苷对直接暴露于脑脊液的结构产生直接毒性作用的假说。
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