体内交感神经刺激引发收缩后平滑肌的舒张。
Relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo.
作者信息
Eccles R, MacLean A G
出版信息
Br J Pharmacol. 1977 Dec;61(4):551-8. doi: 10.1111/j.1476-5381.1977.tb07547.x.
Abstract
- A method for studying in vivo the process of neuroeffector transmission in the nictitating membrane and nasal blood vessels of the cat is described. 2. Administration of desmethylimipramine or cocaine caused increases in both the amplitude and duration of the nasal and membrane responses which may be explained by inhibition of neuronal uptake of noradrenaline. 3. Phenoxybenzamine depressed the responses to nerve stimulation, but had little effect on the relationship between response amplitude and rate of recovery. 4. The relationship between response amplitude and rate of recovery is discussed and related to the sigmoid shape of a log concentration-response curve.
摘要
- 本文描述了一种在猫的瞬膜和鼻血管中体内研究神经效应器传递过程的方法。2. 给予去甲丙咪嗪或可卡因会导致鼻和膜反应的幅度和持续时间增加，这可能是由于去甲肾上腺素的神经元摄取受到抑制所致。3. 酚苄明抑制对神经刺激的反应，但对反应幅度与恢复速率之间的关系影响不大。4. 讨论了反应幅度与恢复速率之间的关系，并将其与对数浓度-反应曲线的S形相关联。
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Relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo.体内交感神经刺激引发收缩后平滑肌的舒张。
Br J Pharmacol. 1977 Dec;61(4):551-8. doi: 10.1111/j.1476-5381.1977.tb07547.x.
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本文引用的文献
1
Impulse frequency in sympathetic vasomotor fibres correlated to the release and elimination of the transmitter.交感缩血管纤维的冲动频率与递质的释放和清除相关。
Acta Physiol Scand. 1952;25(1):49-76. doi: 10.1111/j.1748-1716.1952.tb00858.x.
2
THE ADRENERGIC INNERVATION OF THE NASAL MUCOSA OF CERTAIN MAMMALS.某些哺乳动物鼻黏膜的肾上腺素能神经支配
Acta Otolaryngol. 1965 Jan;59:65-72. doi: 10.3109/00016486509128547.
3
A QUANTITATIVE STUDY OF THE EFFECT OF COCAINE ON THE RESPONSE OF THE CAT NICTITATING MEMBRANE TO NERVE STIMULATION AND TO INJECTED NORADRENALINE.可卡因对猫瞬膜对神经刺激及注射去甲肾上腺素反应影响的定量研究
Br J Pharmacol Chemother. 1964 Feb;22(1):5-21. doi: 10.1111/j.1476-5381.1964.tb01539.x.
4
THE UPTAKE OF NORADRENALINE BY THE ISOLATED PERFUSED RAT HEART.去甲肾上腺素在离体灌注大鼠心脏中的摄取
Br J Pharmacol Chemother. 1963 Dec;21(3):523-37. doi: 10.1111/j.1476-5381.1963.tb02020.x.
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Preganglionic sympathetic activity in normal and in reserpine-treated cats.正常猫和利血平处理猫的节前交感神经活动
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