体外神经外间隙对猫瞬膜舒张的影响。
The influence of an extraneuronal compartment on the relaxation of the cat nictitating membrane in vivo.
作者信息
Eccles R, Maclean A G
出版信息
Br J Pharmacol. 1978 Apr;62(4):563-6. doi: 10.1111/j.1476-5381.1978.tb07762.x.
Abstract
1 Contractions of the cat nictitating membrane were elicited on stimulation of the internal carotid nerve, and the effects were studied of desipramine and two inhibitors of catechol-O-methyltransferase, U-0521 and pyrogallol, on the subsequent relaxation of the muscle. 2 The relaxation of the nictitating membrane occurred in at least two phases. The late phase of relaxation was prolonged after increase in the period of nerve stimulation and the duration of this phase was further prolonged after treatment with pyrogallol. 3 After inhibition of neuronal uptake of noradrenaline with desipramine both the early and late phases of relaxation were increased in duration, and subsequent administration of pyrogallol or U-0521 caused a further increase in the duration of the late phase of relaxation. 4 The results suggest that the late phase of relaxation of the nictitating membrane is influenced by efflux of noradrenaline from an extraneuronal pool.
摘要
- 刺激猫的颈内神经可引起瞬膜收缩，并研究了地昔帕明以及两种儿茶酚-O-甲基转移酶抑制剂U-0521和连苯三酚对随后肌肉松弛的影响。2. 瞬膜的松弛至少分为两个阶段。神经刺激时间增加后，后期松弛阶段延长，用连苯三酚处理后该阶段的持续时间进一步延长。3. 用地昔帕明抑制去甲肾上腺素的神经元摄取后，早期和后期松弛阶段的持续时间均增加，随后给予连苯三酚或U-0521会使后期松弛阶段的持续时间进一步增加。4. 结果表明，瞬膜松弛的后期阶段受去甲肾上腺素从神经外池流出的影响。
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The influence of an extraneuronal compartment on the relaxation of the cat nictitating membrane in vivo.体外神经外间隙对猫瞬膜舒张的影响。
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本文引用的文献
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Augmentation of pharmacological properties of catecholamines by O-methyl transferase inhibitors.
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Uptake of noradrenaline by adrenergic nerves, smooth muscle and connective tissue in isolated perfused arteries and its correlation with the vasoconstrictor response.去甲肾上腺素在离体灌注动脉的肾上腺素能神经、平滑肌和结缔组织中的摄取及其与血管收缩反应的相关性。
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The catechol-O-methyl transferase activity and endogenous catecholamine content of various tissues in the rat and the effect of administration of U-0521 (3',4'-dihydroxy-2-methyl propiophenone).大鼠各种组织中儿茶酚-O-甲基转移酶活性和内源性儿茶胺含量以及U-0521（3'，4'-二羟基-2-甲基苯丙酮）给药的影响。
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Changes in monoamine oxidase and catechol-0-methyl transferase activities after denervation of the nictitating membrane of the cat.猫瞬膜去神经支配后单胺氧化酶和儿茶酚-O-甲基转移酶活性的变化
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Intraneuronal and extraneuronal accumulation of sympathomimetic amines in the isolated nictitating membrane of the cat.猫离体瞬膜中拟交感胺的神经元内和神经元外蓄积
J Pharmacol Exp Ther. 1970 Aug;174(2):290-306.
6
Supersensitivity of the isolated nictitating membrane of the cat to sympathomimetic amines after impairment of the intraneuronal mechanisms of inactivation.猫的隔离瞬膜在神经元内失活机制受损后对拟交感胺的超敏反应。
Naunyn Schmiedebergs Arch Pharmakol. 1971;271(1):29-58.
7
Role of extraneuronal mechanisms in the termination of contractile responses to amines in vascular tissue.血管组织中神经外机制在胺类收缩反应终止中的作用。
Br J Pharmacol. 1975 Feb;53(2):267-77. doi: 10.1111/j.1476-5381.1975.tb07358.x.
8
Relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo.体内交感神经刺激引发收缩后平滑肌的舒张。
Br J Pharmacol. 1977 Dec;61(4):551-8. doi: 10.1111/j.1476-5381.1977.tb07547.x.
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