Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
BJOG. 2010 May;117(6):756-60. doi: 10.1111/j.1471-0528.2010.02527.x. Epub 2010 Mar 12.
Polycystic ovaries and impaired fertility are the result of abnormal folliculogenesis. Our objective was to determine the role of four candidate folliculogenesis genes in the development of polycystic ovary syndrome (PCOS). Women with and without PCOS (335 cases; 198 controls) were genotyped for single nucleotide polymorphisms in GDF9, BMP15, AMH, and AMHR2. Variants in these genes were not associated with PCOS. Certain GDF9 variants were associated with hirsutism scores and parity in PCOS patients. GDF9 may thus serve as a modifier gene. These results suggest that inherited defects in folliculogenesis are not major factors in the genetic susceptibility to PCOS.
多囊卵巢和生育能力受损是卵泡发生异常的结果。我们的目的是确定四个候选卵泡发生基因在多囊卵巢综合征(PCOS)发展中的作用。对患有和不患有 PCOS 的女性(335 例;198 例对照)进行 GDF9、BMP15、AMH 和 AMHR2 单核苷酸多态性的基因分型。这些基因中的变异与 PCOS 无关。某些 GDF9 变异与 PCOS 患者的多毛症评分和产次有关。因此,GDF9 可能是一个修饰基因。这些结果表明,卵泡发生的遗传缺陷不是 PCOS 遗传易感性的主要因素。