抗缪勒管激素（AMH）及其受体单核苷酸多态性（SNP）在多囊卵巢综合征（PCOS）发病机制中的作用。
The role of AMH and its receptor SNP in the pathogenesis of PCOS.
作者信息
Wang Fang, Niu Wen-Bin, Kong Hui-Juan, Guo Yi-Hong, Sun Ying-Pu
机构信息
Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
出版信息
Mol Cell Endocrinol. 2017 Jan 5;439:363-368. doi: 10.1016/j.mce.2016.09.023. Epub 2016 Sep 21.
The etiology of polycystic ovaries syndrome (PCOS) is unknown. Studies probing the role of genetic variants of anti-Mullerian hormone (AMH) and its type II receptor (AMHR2) in the pathogenesis of PCOS have yielded inconsistent results. Thus, we performed a systematic review and meta-analysis to determine the role of genetic variants of AMH/AMHR2 in the pathogenesis of PCOS. A systematic search of electronic databases was performed. Statistical analysis was performed using the Comprehensive Meta-Analysis software (Version 3). Pooled Odds Ratios (OR) (95% confidence intervals) were determined to assess the association between genetic variants of AMH/AMHR2 and PCOS. Five studies, involving a total of 2042 PCOS cases and 1071 controls, were included in the meta-analysis. Single nucleotide polymorphisms of AMH and AMHR2 did not appear to confer a heightened risk for PCOS (OR: 0.954, 95% CI: 0.848-1.073; P = 0.435; and OR: 1.074, 95% CI: 0.875-1.318; P = 0.494, respectively). In this study, genetic variants of AMH or AMHR2 were not found to be associated with a higher risk for PCOS.
多囊卵巢综合征（PCOS）的病因尚不清楚。探究抗苗勒管激素（AMH）及其II型受体（AMHR2）的基因变异在PCOS发病机制中的作用的研究结果并不一致。因此，我们进行了一项系统综述和荟萃分析，以确定AMH/AMHR2基因变异在PCOS发病机制中的作用。我们对电子数据库进行了系统检索。使用综合荟萃分析软件（第3版）进行统计分析。通过合并优势比（OR）（95%置信区间）来评估AMH/AMHR2基因变异与PCOS之间的关联。荟萃分析纳入了5项研究，共涉及2042例PCOS病例和1071例对照。AMH和AMHR2的单核苷酸多态性似乎并未增加PCOS的发病风险（OR分别为：0.954，95%CI：0.848 - 1.073；P = 0.435；以及OR：1.074，95%CI：0.875 - 1.318；P = 0.494）。在本研究中，未发现AMH或AMHR2的基因变异与PCOS的较高发病风险相关。
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