Skin research centre, Shahid Beheshti University, M.C. Shohada-e Tajrish Hospital, 1989934148, Tehran, Iran.
Clin Exp Dermatol. 2010 Aug;35(6):624-6. doi: 10.1111/j.1365-2230.2010.03778.x. Epub 2010 Mar 6.
Isotretinoin has revolutionized the treatment of acne by improving the cosmetic outcome and decreasing the psychological damage. However, use of isotretinoin is associated with significant side-effects such as mucocutaneous involvement, dyslipidaemia and liver dysfunction, as indicated by increases in liver enzymes. The responsible enzyme for homocysteine metabolism, cystathionine-beta-synthase, might also be affected by isotretinoin-induced liver dysfunction, which leads to hyperhomocysteinaemia, an independent risk factor for thrombovascular diseases. The aim of this study was to evaluate homocysteine levels and the responsible vitamins for its metabolism in patients with moderate to severe acne vulgaris on isotretinoin treatment, before and after treatment. We found increased level of homocysteine in patients after 2 months of taking isotretinoin. Our findings suggest that isotretinoin may increase the risk of cardiovascular disorders by causing hyperhomocysteinaemia.
异维 A 酸通过改善美容效果和减少心理伤害，彻底改变了痤疮的治疗方法。然而，异维 A 酸的使用与显著的副作用相关，如粘膜皮肤受累、血脂异常和肝功能障碍，表现为肝酶升高。半胱氨酸-β-合成酶是同型半胱氨酸代谢的关键酶，可能也会受到异维 A 酸引起的肝功能障碍的影响，导致高同型半胱氨酸血症，这是血栓血管疾病的一个独立危险因素。本研究旨在评估中重度寻常痤疮患者在接受异维 A 酸治疗前后同型半胱氨酸水平及其代谢相关维生素的变化。我们发现，患者在服用异维 A 酸 2 个月后同型半胱氨酸水平升高。我们的研究结果表明，异维 A 酸可能通过引起高同型半胱氨酸血症增加心血管疾病的风险。
