Ossenkoppele P M, van der Sluis W G, van Vloten W A
Academisch Ziekenhuis, afd. Dermatologie, Utrecht.
Ned Tijdschr Geneeskd. 1991 Mar 16;135(11):478-80.
The injudicious use of a systemically administered herb containing psoralens derived from the fruits of Ammi majus in combination with exposure of the skin to the sun caused a severe phototoxic dermatitis in a Moroccan patient with vitiligo. She was disappointed in the treatment by the dermatologist. A family member advised her to start the treatment with herbs. The identification of the herbs by microscopic, chromatographic and biological techniques demonstrated that they contained the linear furanocoumarins (psoralens) 5-MOP, 8-MOP and oxypeucedanin each in a concentration of approx. 1%. Because of the large immigrant population in our country we expect to see more cases in the future.
一名患有白癜风的摩洛哥患者,因不合理地使用了一种全身给药的、含有从大阿米芹果实中提取的补骨脂素的草药,并同时让皮肤暴露于阳光下,引发了严重的光毒性皮炎。她对皮肤科医生的治疗感到失望。一名家庭成员建议她开始用草药治疗。通过显微镜、色谱和生物学技术对这些草药进行鉴定,结果表明它们含有浓度约为1%的线性呋喃香豆素(补骨脂素)5-甲氧补骨脂素、8-甲氧补骨脂素和氧化前胡素。由于我国移民人口众多,我们预计未来会出现更多此类病例。