Kornhauser A, Wamer W G, Giles A L
Natl Cancer Inst Monogr. 1984 Dec;66:97-101.
Topical application of 8- and 5-methoxypsoralen (8-MOP, 5-MOP), psoralen, and 4,5',8-trimethylpsoralen (TMP) to the epilated backs of albino guinea pigs followed by UV irradiation at 320-400 nm resulted in elicitation of similar phototoxicity. However, the systemic phototoxicity determined after oral administration of these psoralen derivatives differed significantly. Serum and epidermal levels of 8-MOP, 5-MOP, and TMP were determined 2 hours post administration. We found a linear relationship between serum and epidermal levels of 8-MOP, but the levels of the other psoralen derivatives were significantly lower. We believe that the reduced oral phototoxicity of 5-MOP and TMP relative to 8-MOP in the guinea pig is due to its reduced levels in the epidermis.
将8-甲氧基补骨脂素（8-MOP）、5-甲氧基补骨脂素（5-MOP）、补骨脂素和4,5',8-三甲基补骨脂素（TMP）局部涂抹于白化豚鼠脱毛后的背部，随后在320 - 400nm波长下进行紫外线照射，会引发相似的光毒性。然而，口服这些补骨脂素衍生物后测定的全身光毒性存在显著差异。给药2小时后测定血清和表皮中8-MOP、5-MOP和TMP的水平。我们发现8-MOP的血清水平与表皮水平呈线性关系，但其他补骨脂素衍生物的水平显著较低。我们认为，豚鼠中5-MOP和TMP相对于8-MOP口服光毒性降低是由于其在表皮中的水平降低所致。
