Melloni Paediatria, University of Milan Medical School at Melloni Hospital, Milan, Italy.
Allergy Asthma Proc. 2010 Mar-Apr;31(2):e11-7. doi: 10.2500/aap.2010.31.3323. Epub 2010 Mar 16.
Measuring IgE antibodies is useful in the diagnostic workup of allergy and asthma. This study was designed to assess the value of a new point-of-care test (ImmunoCAP Rapid Wheeze-Rhinitis Child [ICR]; Phadia AB, Uppsala, Sweden) in the diagnosis of atopy in children with allergy-like symptoms such as rhinitis, eczema, and recurrent episodes of wheezing. Patients (n = 175; average age, 7.2 years) referred from primary care were consecutively enrolled in two pediatric allergy referral centers in Italy and were assessed during a single visit. The ICR test included egg, milk, house-dust mite, timothy, mugwort, wall pellitory, birch, olive, cat, and dog allergens. ICR results were consistent with 78% of the positive clinical diagnoses. Agreement between negative ICR results and physician's clinical judgment ranged between 92 and 99% for the single allergens and averaged 96% for the complete profile. Overall agreement of ICR versus clinical diagnosis was 93%. A false positive ICR rate of 1% was recorded. ICR was positive for 94% of the patients with at least one positive clinical diagnosis. Based on the agreement between the physician's assessment of the clinical relevance of each allergen and the ICR results, we concluded that ICR could be a useful tool for primary care physicians to rule in or out the clinical relevance of single ICR allergens.
测定 IgE 抗体对于过敏和哮喘的诊断具有重要意义。本研究旨在评估一种新型即时检测（ImmunoCAP Rapid Wheeze-Rhinitis Child [ICR]；Phadia AB，Uppsala，瑞典）在诊断具有过敏样症状（如鼻炎、湿疹和反复喘息发作）的儿童特应性中的价值。从初级保健机构转诊的患者（n = 175；平均年龄 7.2 岁）连续纳入意大利的两个儿科过敏转诊中心，并在单次就诊时进行评估。ICR 测试包括鸡蛋、牛奶、屋尘螨、豚草、艾蒿、墙草、桦树、橄榄、猫和狗过敏原。ICR 结果与 78%的阳性临床诊断一致。对于单一过敏原，阴性 ICR 结果与医生临床判断之间的一致性在 92%至 99%之间，对于完整的检测谱，平均一致性为 96%。ICR 与临床诊断的总体一致性为 93%。假阳性 ICR 率为 1%。至少有一个阳性临床诊断的患者中，有 94%的 ICR 呈阳性。根据医生对每个过敏原的临床相关性评估与 ICR 结果之间的一致性，我们得出结论，ICR 可能是初级保健医生用于确定或排除单一 ICR 过敏原临床相关性的有用工具。
