Department of Social Medicine, Chonburi Hospital and Medical Education Center, Chonburi, 20000, Thailand.
Alcohol Alcohol. 2010 May-Jun;45(3):263-70. doi: 10.1093/alcalc/agq013. Epub 2010 Mar 17.
To determine the effectiveness of Motivational Enhancement Therapy (MET) for hazardous drinkers in Primary Care Unit (PCU) settings in rural Thailand.
A randomized controlled trial was conducted in eight PCUs in Ubonratchatanee and Chachoengsao provinces in Thailand. Hazardous drinkers were identified using the World Health Organization-recommended Alcohol Use Disorder Identification Test. Of 117 eligible participants (91% male), 59 were randomized to the intervention group to receive MET in three individual appointments with a trained nurse and 58 to an assessment-only control group. Outcome evaluations were carried out after 6 weeks, 3 months and 6 months.
Follow-up data were available on 84, 94 and 91% of subjects, respectively, at the three intervals. Self-reported drinks per drinking day, frequency of hazardous drinking assessed either on a daily or weekly basis, and of binge drinking sessions were reduced in the intervention group more than in the control group (P < 0.05) after both 3 and 6 months. The groups did not generally differ at 6 weeks. However, although self-reported consumption in both groups fell from baseline to 6-month follow-up, serum gamma-glutamyl transferase increased in both groups, which raises doubts about the validity of this marker in this sample and/or the validity of the self-reported data in this study.
MET delivered by nurses in PCUs in Thailand appears to be an effective intervention for male hazardous drinkers. Uncertainties about the validity of self-reported data jeopardize the safety of this conclusion.
在泰国农村的基层医疗单位(PCU)环境中,确定动机增强疗法(MET)对危险饮酒者的有效性。
在泰国乌汶叻差他尼府和乍都乍府的 8 个 PCU 中进行了一项随机对照试验。使用世界卫生组织推荐的酒精使用障碍识别测试来确定危险饮酒者。在 117 名符合条件的参与者(91%为男性)中,59 名被随机分配到干预组,接受由经过培训的护士进行的 3 次个体预约的 MET,58 名被分配到仅评估对照组。在 6 周、3 个月和 6 个月后进行了结果评估。
在这三个时间间隔中,分别有 84%、94%和 91%的受试者可获得随访数据。与对照组相比,干预组在 3 个月和 6 个月后,自我报告的每日饮酒量、每日或每周评估的危险饮酒频率以及狂欢饮酒次数均有所减少(P<0.05)。两组在 6 周时通常没有差异。然而,尽管两组的自我报告饮酒量均从基线降至 6 个月随访时有所下降,但两组的血清γ-谷氨酰转移酶均有所升高,这让人对该样本中该标志物的有效性和/或该研究中自我报告数据的有效性产生了怀疑。
在泰国的 PCU 中,由护士提供的 MET 似乎是一种有效的干预措施,适用于男性危险饮酒者。自我报告数据的有效性存在不确定性,这危及到这一结论的安全性。