Department of Nutrition and Dietetics, VU University Medical Center, Amsterdam, The Netherlands.
Am J Clin Nutr. 2010 May;91(5):1244-54. doi: 10.3945/ajcn.2009.28330. Epub 2010 Mar 17.
When the resting energy expenditure (REE) of overweight and obese adolescents cannot be measured by indirect calorimetry, it has to be predicted with an equation.
The aim of this study was to examine the validity of published equations for REE compared with indirect calorimetry in overweight and obese adolescents.
Predictive equations based on weight, height, sex, age, fat-free mass (FFM), and fat mass were compared with measured REE. REE was measured by indirect calorimetry, and body composition was measured by dual-energy X-ray absorptiometry. The accuracy of the REE equations was evaluated on the basis of the percentage of adolescents predicted within 10% of REE measured, the mean percentage difference between predicted and measured values (bias), and the root mean squared prediction error (RMSE).
Forty-three predictive equations (of which 12 were based on FFM) were included. Validation was based on 70 girls and 51 boys with a mean age of 14.5 y and a mean (+/-SD) body mass index SD score of 2.93 +/- 0.45. The percentage of adolescents with accurate predictions ranged from 74% to 12% depending on the equation used. The most accurate and precise equation for these adolescents was the Molnar equation (accurate predictions: 74%; bias: -1.2%; RMSE: 174 kcal/d). The often-used Schofield-weight equation for age 10-18 y was not accurate (accurate predictions: 50%; bias: +10.7%; RMSE: 276 kcal/d).
Indirect calorimetry remains the method of choice for REE in overweight and obese adolescents. However, the sex-specific Molnar REE prediction equation appears to be the most accurate for overweight and obese adolescents aged 12-18 y. This trial was registered at www.trialregister.nl with the Netherlands Trial Register as ISRCTN27626398.
当超重和肥胖青少年的静息能量消耗（REE）无法通过间接测热法测量时，必须使用方程进行预测。
本研究旨在比较发表的 REE 方程与间接测热法在超重和肥胖青少年中的有效性。
基于体重、身高、性别、年龄、去脂体重（FFM）和脂肪量的预测方程与测量的 REE 进行比较。REE 通过间接测热法测量，身体成分通过双能 X 射线吸收法测量。REE 方程的准确性基于以下几个方面进行评估：预测的青少年中，有 10%的人在 REE 测量值的 10%以内的比例、预测值与实测值之间的平均百分比差异（偏差）以及均方根预测误差（RMSE）。
共纳入 43 个预测方程（其中 12 个基于 FFM）。验证基于 70 名女孩和 51 名男孩，平均年龄为 14.5 岁，平均（+/-SD）体重指数 SD 评分为 2.93 +/- 0.45。使用不同方程时，预测准确的青少年比例从 74%到 12%不等。对于这些青少年来说，最准确和精确的方程是 Molnar 方程（准确预测：74%；偏差：-1.2%；RMSE：174 kcal/d）。常用的 Schofield-weight 方程对于 10-18 岁的青少年并不准确（准确预测：50%；偏差：+10.7%；RMSE：276 kcal/d）。
间接测热法仍然是超重和肥胖青少年 REE 的首选方法。然而，对于 12-18 岁的超重和肥胖青少年，性别特异性 Molnar REE 预测方程似乎是最准确的。本试验在 www.trialregister.nl 上向荷兰临床试验注册中心（NTR）注册，注册号为 ISRCTN27626398。
