一种真菌高还原型聚酮合酶的C-甲基转移酶结构域中关键残基的突变
Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase.
作者信息
Skellam Elizabeth J, Hurley Deirdre, Davison Jack, Lazarus Colin M, Simpson Thomas J, Cox Russell J
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
出版信息
Mol Biosyst. 2010 Apr;6(4):680-2. doi: 10.1039/b923990a. Epub 2010 Feb 10.
DOI:10.1039/b923990a
PMID:20237645
Abstract
Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production.
摘要
对鲨烯抑素四酮合酶的C-甲基转移酶结构域进行定点突变，试图改变体内表达的合酶的甲基化模式：突变要么没有效果，要么导致聚酮化合物的产生完全消除。
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