酒精诱导的肝细胞细胞骨架改变。
Alcohol-induced alterations of the hepatocyte cytoskeleton.
机构信息
Department of Biology, The Catholic University of America, 620 Michigan Avenue NE, Washington, DC 20064, USA.
出版信息
World J Gastroenterol. 2010 Mar 21;16(11):1358-65. doi: 10.3748/wjg.v16.i11.1358.
Abstract
The hepatocyte cytoskeleton consists of three filamentous networks: microtubules, actin microfilaments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three filament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifications. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease.
摘要
肝细胞的细胞骨架由三种丝状网络组成
微管、肌动蛋白微丝和角蛋白中间丝。由于构成每个系统的蛋白质丰富，以及每个网络在各种细胞过程中所起的核心作用，这三个丝状系统一直是众多旨在了解酒精性肝损伤进展的研究的焦点。在这篇综述中，我们将简要讨论每个细胞骨架网络的肝组织，并强调每个系统的一些组成部分。我们还将描述乙醇诱导的每个细胞骨架系统的动力学和分布变化，以及已知的关于蛋白质表达水平和翻译后修饰变化的情况。最后，我们将描述这些细胞骨架改变对肝细胞功能的可能影响，以及它们如何促成肝病的进展。
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