酒精：基础与转化研究；第 15 届查尔斯·利伯与第 1 届塞缪尔·弗伦奇卫星研讨会。
Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.
机构信息
In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.
Centre of Liver and Alcohol Diseases, Ethianum Clinic, University of Heidelberg, Germany.
出版信息
Exp Mol Pathol. 2022 Jun;126:104750. doi: 10.1016/j.yexmp.2022.104750. Epub 2022 Feb 19.
The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.
本综述基于在专题研讨会上提交的研究成果，该研讨会旨在纪念两位在酒精性肝损伤领域做出重要发现的科学家：C.S. 利伯教授和 S.W. 弗伦奇教授。受邀演讲者描述了酒精滥用的药理学、毒理学和病理生理学效应。此外，还讨论了由于用于慢性或传染病的治疗药物与酒精暴露之间的相互作用而导致不良药物反应的遗传生物标志物。研究人员展示了他们在酒精引起的脂质蛋白转运和内吞作用障碍以及脂质在脂肪肝发展中的作用等领域的工作。研究人员表明，酒精会导致促进肝功能障碍和损伤的共价修饰。我们的结论是，使用新的先进技术和研究思路会推动科学领域的重要发现。
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