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抗肿瘤药物顺式二氯二氨合铂（II）与嵌入剂N-甲基-2,7-二氮杂芘之间反应中DNA可能的催化活性。

Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.

作者信息

Gaucheron F, Malinge J M, Blacker A J, Lehn J M, Leng M

机构信息

Centre de Biophysique Moléculaire, Orléans, France.

出版信息

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3516-9. doi: 10.1073/pnas.88.9.3516.

DOI:10.1073/pnas.88.9.3516
PMID:2023897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51482/
Abstract

The platinum(II) complex cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl]2+ formed in the reaction between cis-diamminedichloroplatinum(II) and N-methyl-2,7-diazapyrenium reacts with N7 of guanine residues in DNA. The resulting adduct is kinetically inert within single-stranded DNA. Within double-stranded DNA, it is kinetically inert in 1 M NaClO4 and becomes labile as the salt concentration is decreased. Two products, cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)H2O]3+ and N-methyl-2,7-diazapyrenium, are released. The conformation of the platinated DNA is different in low- and high-salt conditions as shown by the chemical probe diethyl pyrocarbonate. These results are discussed in relation with a possible catalytic role played by the double-stranded DNA.

摘要

顺式二氯二氨合铂（II）与N-甲基-2,7-二氮杂芘反应生成的铂（II）配合物顺式-[Pt(NH₃)₂(N⁷-N-甲基-2-二氮杂芘鎓)Cl]²⁺与DNA中鸟嘌呤残基的N⁷发生反应。生成的加合物在单链DNA中动力学惰性。在双链DNA中，它在1 M高氯酸钠中动力学惰性，随着盐浓度降低变得不稳定。会释放出两种产物，顺式-[Pt(NH₃)₂(N⁷-N-甲基-2-二氮杂芘鎓)H₂O]³⁺和N-甲基-2,7-二氮杂芘。如焦碳酸二乙酯化学探针所示，在低盐和高盐条件下，铂化DNA的构象不同。结合双链DNA可能发挥的催化作用对这些结果进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/7299cc6ccdf6/pnas01059-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/e8aa90e30e02/pnas01059-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/9fa8f462ac8d/pnas01059-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/7299cc6ccdf6/pnas01059-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/e8aa90e30e02/pnas01059-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/9fa8f462ac8d/pnas01059-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33da/51482/7299cc6ccdf6/pnas01059-0018-a.jpg

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Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution.DNA构象的化学探针：核苷酸分辨率下Z-DNA的检测
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Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8147-51. doi: 10.1073/pnas.91.17.8147.
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Nucleic Acids Res. 1992 Sep 25;20(18):4825-30. doi: 10.1093/nar/20.18.4825.
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The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes.抗癌铂配合物产生的DNA加合物的形成、分离及特性分析
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