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脊髓灰质炎:流行病学与预防。4. 在为控制一场有威胁的脊髓灰质炎疫情而开展大规模疫苗接种运动后进行的血清学和病毒学调查。

Poliomyelitis: epidemiology and prophylaxis. 4. Serological and virological surveys conducted after a mass vaccination campaign for the control of a threatening poliomyelitis epidemic.

作者信息

Metselaar D, McDonald K, Gemert W, Nottay B, Muli J M

出版信息

Bull World Health Organ. 1977;55(6):747-53.

Abstract

In 1973, a type 1 poliomyelitis epidemic in Kenya was curtailed at an early stage by two mass distributions of trivalent oral vaccine. It was considered useful to know the immunity status of the child population that had resulted from the vaccine distributions and that had presumably contributed to its control. We also wished to know to what extent wild and vaccine virus strains were in circulation after the mass vaccination campaign. Anal swabs and blood were collected from a sample of the children in four areas where the efficiency of vaccine distribution had varied, and the results of virus isolation attempts and antibody tests are reported. Three poliovirus strains were isolated. It was surprising that, in general, the herd immunity after two vaccination rounds did not substantially differ from that found in Kenya on other occasions. Possible reasons for these results are discussed.

摘要

1973年,肯尼亚的一场1型脊髓灰质炎疫情通过两次大规模分发三价口服疫苗在早期得到了控制。了解疫苗分发后儿童群体的免疫状况以及这种状况可能对疫情控制所做的贡献被认为是有益的。我们还想知道在大规模疫苗接种运动之后野生病毒株和疫苗病毒株的传播程度。从疫苗分发效率不同的四个地区的儿童样本中采集了肛拭子和血液,并报告了病毒分离尝试和抗体检测的结果。分离出了三种脊髓灰质炎病毒株。令人惊讶的是,总体而言,两轮疫苗接种后的群体免疫与肯尼亚其他情况下的群体免疫没有实质性差异。文中讨论了这些结果可能的原因。

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Seroimmunity to poliomyelitis in an American community.美国一个社区对脊髓灰质炎的血清免疫情况。
Am J Epidemiol. 1975 Apr;101(4):333-9. doi: 10.1093/oxfordjournals.aje.a112101.

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