Kario K, Matsuo T
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital.
Nihon Ronen Igakkai Zasshi. 1991 Sep;28(5):668-71. doi: 10.3143/geriatrics.28.668.
To study the relationship between serum uric acid, lipid fractions, and coagulation factor VII (FVII) in the elderly, we measured FVII coagulation activity (FVIIc). FVII antigen (FVIIag), in 138 normal subjects without alcohol intake ranging in age from 60 to 98 years. We also measured blood lipid fractions including apolipoprotein A-I, A-II, B, E, and serum cholinesterase activity (ChE). Serum uric acid levels significantly correlated with FVIIc (p less than 0.01) and FVIIag levels (p less than 0.05) as well as with tryglycerides, VLDL, LDL, total cholesterol, and ChE in elderly men, but not in women. However, multiple regression analysis showed these correlations in elderly men were not significant, after excluding the effect of triglycerides and VLDL. These results also suggest that elevation of uric acid may be a coronary risk factor in elderly men through high FVII levels.
为研究老年人血清尿酸、血脂组分与凝血因子VII（FVII）之间的关系，我们测定了138名年龄在60至98岁之间、无饮酒习惯的正常受试者的FVII凝血活性（FVIIc）、FVII抗原（FVIIag）。我们还测定了血脂组分，包括载脂蛋白A-I、A-II、B、E以及血清胆碱酯酶活性（ChE）。血清尿酸水平与老年男性的FVIIc（p<0.01）、FVIIag水平（p<0.05）以及甘油三酯、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、总胆固醇和ChE显著相关，但与老年女性无关。然而，多元回归分析显示，在排除甘油三酯和VLDL的影响后，老年男性中的这些相关性并不显著。这些结果还表明，尿酸升高可能通过高水平的FVII成为老年男性的冠状动脉危险因素。
