Boshkov L K, Tredget E E, Janowska-Wieczorek A
Department of Medicine, University of Alberta Hospital, Edmonton, Canada.
Am J Hematol. 1991 May;37(1):53-4. doi: 10.1002/ajh.2830370113.
We report the use of recombinant human erythropoietin (rh-Ep) as an alternative to transfusion therapy in a burn victim who was a Jehovah's Witness and refused blood transfusion. Despite endogenous elevated erythropoietin levels, the patient was reticulocytopenic and administration of rh-Ep was accompanied by a 10-fold increase in reticulocyte response and a rise in hemoglobin from 7.4 to 10.4 g/dl over a 12-day period. We suggest that the exogenously administered erythropoietin overcame a clinically inadequate endogenous erythropoietin response.
我们报告了在一名耶和华见证会成员且拒绝输血的烧伤患者中，使用重组人促红细胞生成素（rh-Ep）替代输血治疗的情况。尽管患者内源性促红细胞生成素水平升高，但仍存在网织红细胞减少，给予rh-Ep后，网织红细胞反应增加了10倍，血红蛋白在12天内从7.4 g/dl升至10.4 g/dl。我们认为，外源性给予的促红细胞生成素克服了临床上内源性促红细胞生成素反应不足的情况。
