Jongejan R C, De Jongste J C, Kerrebijn K F
Department of Paediatrics, University Hospital Rotterdam/Sophia Children's Hospital, The Netherlands.
Am Rev Respir Dis. 1991 May;143(5 Pt 1):1194-6. doi: 10.1164/ajrccm/143.5_Pt_1.1194.
In asthma the dose-response curve to inhaled methacholine (MCh) is shifted leftwards and shows an increased slope and maximum. Two factors might contribute to the different form and position of this curve: (1) mediator-induced airway muscle hypersensitivity and (2) thickening of the airway wall. We attempted to estimate the effect of a combination of these two factors on the increase in airway resistance of a single isolated human airway to increasing concentrations of MCh. The result suggests that mediator-induced hypersensitivity to cholinergic stimuli may explain a small part of the leftward shift of the asthmatic dose-response curve to MCh, especially at lower levels of bronchoconstriction, and that increased thickness of the airway wall may be more important for the increased slope and maximum of the asthmatic dose-response curve.
在哮喘中，对吸入乙酰甲胆碱（MCh）的剂量反应曲线向左移动，且斜率和最大值增加。有两个因素可能导致该曲线的不同形态和位置：（1）介质诱导的气道平滑肌超敏反应和（2）气道壁增厚。我们试图评估这两个因素的组合对单个离体人类气道对递增浓度MCh的气道阻力增加的影响。结果表明，介质诱导的对胆碱能刺激的超敏反应可能解释了哮喘剂量反应曲线对MCh向左移动的一小部分，尤其是在支气管收缩程度较低时，并且气道壁厚度增加对于哮喘剂量反应曲线斜率和最大值的增加可能更为重要。
