Hanning I, Seth J, Bacon R R, Hunter W M, al-Sadie R
Department of Clinical Chemistry, University of Edinburgh, UK.
Ann Clin Biochem. 1991 Jan;28 ( Pt 1):91-7. doi: 10.1177/000456329102800116.
The quality of serum prolactin assays routinely performed by UK laboratories has been monitored in an external quality assessment scheme (EQAS) over a 10-year period, during which participation in the EQAS increased three-fold, and considerable changes in methods and standardization were introduced. The all-laboratory mean was used as the sample target value, and proved to be stable and accurate. Overall between-laboratory agreement in the clinically important range improved from a geometric coefficient of variation (GCV) of 25% to 14%. This appears to reflect the increased use of kits in place of 'in-house' assays, the more widespread availability of international standards and the absence of any marked differences in bias between the commonly used methods. Published guidelines on the clinical interpretation of prolactin values should, therefore, be widely applicable. The EQAS data indicate that, in general, the quality of performance of prolactin assays is adequate for their clinical application.
在一项外部质量评估计划（EQAS）中，对英国实验室常规进行的血清催乳素检测质量进行了为期10年的监测。在此期间，参与EQAS的实验室数量增加了两倍，并且在方法和标准化方面引入了相当大的变化。将所有实验室的均值用作样本目标值，结果证明该值稳定且准确。在临床重要范围内，实验室间总体一致性从几何变异系数（GCV）25%提高到了14%。这似乎反映了试剂盒取代“内部”检测方法的使用增加、国际标准的更广泛可得性以及常用方法之间在偏差方面没有任何显著差异。因此，关于催乳素值临床解读的已发表指南应具有广泛适用性。EQAS数据表明，总体而言，催乳素检测的性能质量足以满足其临床应用需求。
