多发性硬化症病因学综述：一种生态学方法

A review of the aetiology of multiple sclerosis: an ecological approach.

作者信息

Murrell T G, Harbige L S, Robinson I C

机构信息

Department of Community Medicine, University of Adelaide, Australia.

出版信息

Ann Hum Biol. 1991 Mar-Apr;18(2):95-112. doi: 10.1080/03014469100001442.

DOI:10.1080/03014469100001442

PMID:2024951

Abstract

Multiple sclerosis (MS) is a disease of unknown aetiology characterized by myelin destruction. Approaches to the aetiology of the condition have noted its differential geographic and demographic distribution; a tentative and inconsistent link with infectious agents; a genetic susceptibility; and a tendency to track with dietary lipids. This review proposes a multidisciplinary approach to the aetiology of MS, emphasizing the interlocking and interdependent nature of current aetiological arguments. We suggest that the most profitable interpretation of current empirical data on the aetiology of MS can be accomplished through this kind of analysis.

摘要

多发性硬化症（MS）是一种病因不明的疾病，其特征为髓鞘破坏。对该病症病因的研究方法已注意到其在地理和人口分布上的差异；与感染因子存在初步且不一致的联系；具有遗传易感性；以及与饮食中的脂质有关联。本综述提出了一种针对MS病因的多学科研究方法，强调当前病因学观点之间相互关联和相互依存的性质。我们认为，通过这种分析能够对目前关于MS病因的实证数据做出最有益的解读。