氧氟沙星在健康志愿者中的生物利用度和药代动力学。 需要说明的是，原英文文本中“of ofloxacin”表述有误，多了一个“of” 。
Bioavailability and pharmacokinetics of ofloxacin in healthy volunteers.
作者信息
Yuk J H, Nightingale C H, Quintiliani R, Sweeney K R
机构信息
Pharmacy Services, Methodist Hospital, Houston, Texas 77030.
出版信息
Antimicrob Agents Chemother. 1991 Feb;35(2):384-6. doi: 10.1128/AAC.35.2.384.
Abstract
The pharmacokinetics and bioavailability of ofloxacin in 20 healthy male volunteers were studied in an open-label, randomized, two-way crossover study. Ofloxacin (400 mg) was administered either as a 1-h infusion or as an oral tablet. The mean peak concentration after intravenous infusion was 4.30 +/- 0.69 microgram/ml, and that after oral administration was 3.14 +/- 0.53 microgram/ml, occurring 1.74 +/- 0.57 h after dosing. The bioavailability (F) of the oral dosage form of ofloxacin was virtually identical to that of the intravenous form (F = 105% +/- 7%). This complete bioavailability of ofloxacin is supportive of the use of the oral dosage form for the treatment of infections in hospitalized patients either as a replacement for intravenous ofloxacin therapy or in streamlining therapy from the intravenous to the oral route.
摘要
在一项开放标签、随机、双向交叉研究中，对20名健康男性志愿者进行了氧氟沙星的药代动力学和生物利用度研究。氧氟沙星（400毫克）以1小时静脉输注或口服片剂的形式给药。静脉输注后的平均峰浓度为4.30±0.69微克/毫升，口服给药后的平均峰浓度为3.14±0.53微克/毫升，在给药后1.74±0.57小时出现。氧氟沙星口服剂型的生物利用度（F）与静脉剂型几乎相同（F = 105%±7%）。氧氟沙星的这种完全生物利用度支持在住院患者中使用口服剂型治疗感染，既可以替代静脉氧氟沙星治疗，也可以简化从静脉到口服途径的治疗。
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本文引用的文献
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