Lode H, Höffken G, Prinzing C, Glatzel P, Wiley R, Olschewski P, Sievers B, Reimnitz D, Borner K, Koeppe P
Medical Department of Klinikum Steglitz, Freie Universität, Berlin.
Drugs. 1987;34 Suppl 1:21-5. doi: 10.2165/00003495-198700341-00006.
The pharmacokinetic properties of the new quinolones are characterised by a high volume of distribution, long biological half-life, low serum protein binding, elimination mainly by the kidneys, high total and renal clearances, limited biotransformation and a moderate to excellent bioavailability after oral administration. However, each quinolone derivative (ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin) possesses individual pharmacokinetic characteristics, which should be considered in the treatment of patients, especially when liver and/or renal dysfunction exists.
新型喹诺酮类药物的药代动力学特性表现为分布容积大、生物半衰期长、血清蛋白结合率低、主要经肾脏排泄、总清除率和肾清除率高、生物转化有限以及口服给药后生物利用度中等至极佳。然而，每种喹诺酮衍生物（环丙沙星、依诺沙星、诺氟沙星、氧氟沙星和培氟沙星）都具有各自的药代动力学特征，在治疗患者时应予以考虑，尤其是存在肝和/或肾功能不全的情况。
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