一名患有胰岛细胞调节异常综合征的早产儿对生长抑素类似物的耐受性
Tolerance to somatostatin analogue in a preterm infant with islet cell dysregulation syndrome.
作者信息
Hawdon J M, Ward Platt M P, Lamb W H, Aynsley-Green A
机构信息
Department of Child Health, Princess Mary Hospital, Newcastle upon Tyne.
出版信息
Arch Dis Child. 1991 Mar;66(3):341-3. doi: 10.1136/adc.66.3.341.
Abstract
An infant of 31 weeks' gestation presented with refractory neonatal hypoglycaemia secondary to islet cell dysregulation. Treatment was started with somatostatin analogue and his glycaemic control improved initially. Tolerance developed, however, in that the dose required to maintain control increased by a factor of 40. The infant subsequently underwent pancreatectomy. It is safe to use somatostatin analogue in a preterm infant, but tolerance to the drug rapidly develops.
摘要
一名孕31周的婴儿因胰岛细胞调节异常出现难治性新生儿低血糖。开始使用生长抑素类似物治疗，其血糖控制最初有所改善。然而，出现了耐受性，即维持控制所需的剂量增加了40倍。该婴儿随后接受了胰腺切除术。在早产儿中使用生长抑素类似物是安全的，但对该药物的耐受性会迅速发展。
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Effect of somatostatin infusion on intermediary metabolism and entero-insular hormone release in infants with hyperinsulinaemic hypoglycaemia.生长抑素输注对高胰岛素血症低血糖婴儿中间代谢及肠-胰岛激素释放的影响。
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