Briddon S, Beck S A, Tisdale M J
CRC Experimental Chemotherapy Group, Aston University, Birmingham, U.K.
Cancer Lett. 1991 Apr;57(1):49-53. doi: 10.1016/0304-3835(91)90062-m.
The effect of weight loss during cancer cachexia on the plasma levels of free fatty acids (FFA) and triglycerides, and on the tissue levels of lipoprotein lipase (LPL), has been studied in mice bearing an experimental colon adenocarcinoma (MAC16). Despite extensive mobilisation of host body fat reserves, plasma levels of triglycerides were reduced irrespective of the extent of weight loss. The plasma levels of FFA also showed an initial decrease with weight loss, followed by a rise peaking at a weight loss of about 2 g, and thereafter the levels decreased with increasing weight loss. The level of LPL in both heart and adipose tissue showed an initial rise with increasing weight loss also peaking at a weight loss of approximately 2.5 g, followed by a decrease with further weight loss. The increased LPL would provide an increased level of fatty acids for oxidation in the cachectic state and would account for the effect on plasma FFAs and triglycerides.
在患有实验性结肠腺癌（MAC16）的小鼠中，研究了癌症恶病质期间体重减轻对游离脂肪酸（FFA）和甘油三酯血浆水平以及脂蛋白脂肪酶（LPL）组织水平的影响。尽管宿主身体脂肪储备大量动员，但无论体重减轻程度如何，甘油三酯血浆水平均降低。FFA血浆水平也随着体重减轻而最初下降，随后上升，在体重减轻约2 g时达到峰值，此后随着体重减轻增加而下降。心脏和脂肪组织中的LPL水平最初随着体重减轻增加而上升，也在体重减轻约2.5 g时达到峰值，随后随着体重进一步减轻而下降。LPL增加会在恶病质状态下为氧化提供更高水平的脂肪酸，并解释对血浆FFA和甘油三酯的影响。
