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尿液酸化对过量服用时血浆和尿液中苯环利定水平的影响。

Effects of urine acidification on plasma and urine phencyclidine levels in overdosage.

作者信息

Domino E F, Wilson A E

出版信息

Clin Pharmacol Ther. 1977 Oct;22(4):421-4. doi: 10.1002/cpt1977224421.

DOI:10.1002/cpt1977224421
PMID:20261
Abstract

A gas chromatography--mass fragmentography--electron impact (GC-MS-EI) assay of phencyclidine (PCP) was adapted for human plasma and urine. This assay is specific for PCP and very sensitive (approximately 1 ng/ml). Patients with the putative diagnosis of PCP overdosage were studied to correlate plasma and urinary levels with clinical state. Urinary PCP levels were enhanced in an acid urine, which suggests that acidification of the urine is an adjunct in the therapy of PCP overdosage.

摘要

一种用于苯环利定(PCP)的气相色谱 - 质量碎片分析法 - 电子轰击(GC-MS-EI)被应用于人体血浆和尿液检测。该检测方法对PCP具有特异性且非常灵敏(约1纳克/毫升)。对疑似PCP过量中毒的患者进行了研究,以关联血浆和尿液水平与临床状态。酸性尿液中的尿PCP水平会升高,这表明尿液酸化是PCP过量中毒治疗中的一种辅助手段。

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Effects of urine acidification on plasma and urine phencyclidine levels in overdosage.尿液酸化对过量服用时血浆和尿液中苯环利定水平的影响。
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